A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S....

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pham Thanh, Duy, Karkey, Abhilasha, Dongol, Sabina, Ho Thi, Nhan, Thompson, Corinne N, Rabaa, Maia A, Arjyal, Amit, Holt, Kathryn E, Wong, Vanessa, Tran Vu Thieu, Nga, Voong Vinh, Phat, Ha Thanh, Tuyen, Pradhan, Ashish, Shrestha, Saroj Kumar, Gajurel, Damoder, Pickard, Derek, Parry, Christopher M, Dougan, Gordon, Wolbers, Marcel, Dolecek, Christiane, Thwaites, Guy E, Basnyat, Buddha, Baker, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Epidemiology and Global Health
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805543/
https://ncbi.nlm.nih.gov/pubmed/26974227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14003
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