A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Pham Thanh, Duy, Karkey, Abhilasha, Dongol, Sabina, Ho Thi, Nhan, Thompson, Corinne N, Rabaa, Maia A, Arjyal, Amit, Holt, Kathryn E, Wong, Vanessa, Tran Vu Thieu, Nga, Voong Vinh, Phat, Ha Thanh, Tuyen, Pradhan, Ashish, Shrestha, Saroj Kumar, Gajurel, Damoder, Pickard, Derek, Parry, Christopher M, Dougan, Gordon, Wolbers, Marcel, Dolecek, Christiane, Thwaites, Guy E, Basnyat, Buddha, Baker, Stephen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Epidemiology and Global Health
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805543/
https://ncbi.nlm.nih.gov/pubmed/26974227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14003
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