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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions, such as inflammation. Therefore, we have assessed the...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Mitchell, J A, Akarasereenont, P, Thiemermann, C, Flower, R J, Vane, J R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 1993
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48050/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265610/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11693
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