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In vitro and in vivo drug disposition of cilengitide in animals and human
Cilengitide is very low permeable (1.0 nm/sec) stable cyclic pentapeptide containing an Arg‐Gly‐Asp motif responsible for selective binding to αvβ3 and αvβ5 integrins administered intravenously (i.v.). In vivo studies in the mouse and Cynomolgus monkeys showed the major component in plasma was uncha...
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| 出版年: | Pharmacol Res Perspect |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4804314/ https://ncbi.nlm.nih.gov/pubmed/27069630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.217 |
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