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In vitro and in vivo drug disposition of cilengitide in animals and human
Cilengitide is very low permeable (1.0 nm/sec) stable cyclic pentapeptide containing an Arg‐Gly‐Asp motif responsible for selective binding to αvβ3 and αvβ5 integrins administered intravenously (i.v.). In vivo studies in the mouse and Cynomolgus monkeys showed the major component in plasma was uncha...
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| Publicado no: | Pharmacol Res Perspect |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4804314/ https://ncbi.nlm.nih.gov/pubmed/27069630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.217 |
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