ATX-LPA(1) axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation

The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G protein-coupled receptors to mediate both unique and overlapping biological effects, including cell migration, proliferation and survival. LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, fro...

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Publicado en:Sci Rep
Main Authors: Nishioka, Tatsuji, Arima, Naoaki, Kano, Kuniyuki, Hama, Kotaro, Itai, Eriko, Yukiura, Hiroshi, Kise, Ryoji, Inoue, Asuka, Kim, Seok-Hyung, Solnica-Krezel, Lilianna, Moolenaar, Wouter H., Chun, Jerold, Aoki, Junken
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804234/
https://ncbi.nlm.nih.gov/pubmed/27005960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23433
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