Validation and Genomic Interrogation of the MET Variant rs11762213 as a Predictor of Adverse Outcomes in Clear Cell Renal Cell Carcinoma

BACKGROUND: The exonic single nucleotide variant rs11762213 located in the MET oncogene has recently been identified as a prognostic marker in clear cell renal cell carcinoma (ccRCC). We validated this finding using the Cancer Genome Atlas cohort and explored the biologic implications. METHODS: Geno...

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Publicat a:Cancer
Autors principals: Hakimi, A. Ari, Ostrovnaya, Irina, Jacobsen, Anders, Susztak, Katalin, Coleman, Jonathan A., Russo, Paul, Winer, Andrew G., Mano, Roy, Sankin, Alexander I., Motzer, Robert J., Voss, Martin H., Offit, Kenneth, Purdue, Mark, Pomerantz, Mark, Freedman, Matthew, Choueiri, Toni K., Hsieh, James J., Klein, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803437/
https://ncbi.nlm.nih.gov/pubmed/26505625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29765
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