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Alloantibodies to therapeutic factor VIII in hemophilia A: the role of von Willebrand factor in regulating factor VIII immunogenicity

The rising incidence of neutralizing antibodies (inhibitors) against therapeutic factor VIII prompted the conduct of studies to answer the question as to whether this rise is related to the introduction of recombinant factor VIII products. The present article summarizes current opinions and results...

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Bibliographic Details
Published in:Haematologica
Main Authors: Oldenburg, Johannes, Lacroix-Desmazes, Sébastien, Lillicrap, David
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803147/
https://ncbi.nlm.nih.gov/pubmed/25638804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.112821
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