Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice

The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defecti...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Lachaud, Christophe, Slean, Meghan, Marchesi, Francesco, Lock, Claire, Odell, Edward, Castor, Dennis, Toth, Rachel, Rouse, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2016
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803050/
https://ncbi.nlm.nih.gov/pubmed/26980188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276287.115
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