Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice

The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defecti...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Lachaud, Christophe, Slean, Meghan, Marchesi, Francesco, Lock, Claire, Odell, Edward, Castor, Dennis, Toth, Rachel, Rouse, John
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803050/
https://ncbi.nlm.nih.gov/pubmed/26980188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276287.115
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