Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

BACKGROUND: Existing rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is gradually reduced, followed by subsequent progres...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Heart Assoc
Prif Awduron: Hattori, Yorito, Enmi, Jun‐ichiro, Iguchi, Satoshi, Saito, Satoshi, Yamamoto, Yumi, Tsuji, Masahiro, Nagatsuka, Kazuyuki, Kalaria, Rajesh N., Iida, Hidehiro, Ihara, Masafumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802480/
https://ncbi.nlm.nih.gov/pubmed/26903005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002757
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