Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

BACKGROUND: Existing rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is gradually reduced, followed by subsequent progres...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Hattori, Yorito, Enmi, Jun‐ichiro, Iguchi, Satoshi, Saito, Satoshi, Yamamoto, Yumi, Tsuji, Masahiro, Nagatsuka, Kazuyuki, Kalaria, Rajesh N., Iida, Hidehiro, Ihara, Masafumi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802480/
https://ncbi.nlm.nih.gov/pubmed/26903005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002757
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