Liver-specific Deletion of Augmenter of Liver Regeneration Accelerates Development of Steatohepatitis and Hepatocellular Carcinoma in Mice

BACKGROUND & AIMS: Augmenter of liver regeneration (ALR, encoded by GFER) is a widely distributed pleiotropic protein originally identified as a hepatic growth factor. However, little is known about its roles in hepatic physiology and pathology. We created mice with liver-specific deletion of AL...

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Publicado no:Gastroenterology
Main Authors: Gandhi, Chandrashekhar R., Chaillet, J. Richard, Nalesnik, Michael A., Kumar, Sudhir, Dangi, Anil, Demetris, A. Jake, Ferrell, Robert, Wu, Tong, Divanovic, Senad, Stankeiwicz, Traci, Shaffer, Benjamin, Stolz, Donna B., Harvey, Stephen A.K., Wang, Jiang, Starzl, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802363/
https://ncbi.nlm.nih.gov/pubmed/25448926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.10.008
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