Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors

The FGFs/FGFRs system is a recognized actionable target for therapeutic approaches aimed at inhibiting tumor growth, angiogenesis, metastasis, and resistance to therapy. We previously identified a non-peptidic compound (SM27) that retains the structural and functional properties of the FGF2-binding...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Foglieni, Chiara, Pagano, Katiuscia, Lessi, Marco, Bugatti, Antonella, Moroni, Elisabetta, Pinessi, Denise, Resovi, Andrea, Ribatti, Domenico, Bertini, Sabrina, Ragona, Laura, Bellina, Fabio, Rusnati, Marco, Colombo, Giorgio, Taraboletti, Giulia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802308/
https://ncbi.nlm.nih.gov/pubmed/27000667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23432
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