Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule

Fibroblast growth factors (FGFs) are recognized targets for the development of therapies against angiogenesis-driven diseases, including cancer. The formation of a ternary complex with the transmembrane tyrosine kinase receptors (FGFRs), and heparan sulphate proteoglycans (HSPGs) is required for FGF...

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Detalhes bibliográficos
Main Authors: Pagano, Katiuscia, Torella, Rubben, Foglieni, Chiara, Bugatti, Antonella, Tomaselli, Simona, Zetta, Lucia, Presta, Marco, Rusnati, Marco, Taraboletti, Giulia, Colombo, Giorgio, Ragona, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351436/
https://ncbi.nlm.nih.gov/pubmed/22606323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036990
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