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Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction that is essential for bone development, however, how IFT proteins regulate Hh signalling in osteoblasts (OBs) remains unclear. Here we show that deletion of ciliary IFT80 in OB precursor cells (OPC) in mic...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Yuan, Xue, Cao, Jay, He, Xiaoning, Serra, Rosa, Qu, Jun, Cao, Xu, Yang, Shuying
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802171/
https://ncbi.nlm.nih.gov/pubmed/26996322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11024
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