Genome-Wide Study of Response to Platinum, Taxane, and Combination Therapy in Ovarian Cancer: In vitro Phenotypes, Inherited Variation, and Disease Recurrence

Background: The standard treatment for epithelial ovarian cancer (EOC) patients with advanced disease is carboplatin-paclitaxel combination therapy following initial debulking surgery, yet there is wide inter-patient variation in clinical response. We sought to identify pharmacogenomic markers relat...

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Vydáno v:Front Genet
Hlavní autoři: Fridley, Brooke L., Ghosh, Taraswi M., Wang, Alice, Raghavan, Rama, Dai, Junqiang, Goode, Ellen L., Lamba, Jatinder K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801852/
https://ncbi.nlm.nih.gov/pubmed/27047539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00037
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