Genome-Wide Study of Response to Platinum, Taxane, and Combination Therapy in Ovarian Cancer: In vitro Phenotypes, Inherited Variation, and Disease Recurrence

Background: The standard treatment for epithelial ovarian cancer (EOC) patients with advanced disease is carboplatin-paclitaxel combination therapy following initial debulking surgery, yet there is wide inter-patient variation in clinical response. We sought to identify pharmacogenomic markers relat...

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Veröffentlicht in:Front Genet
Hauptverfasser: Fridley, Brooke L., Ghosh, Taraswi M., Wang, Alice, Raghavan, Rama, Dai, Junqiang, Goode, Ellen L., Lamba, Jatinder K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801852/
https://ncbi.nlm.nih.gov/pubmed/27047539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00037
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