Tumor vaccines with dsRNA adjuvant ARNAX induces antigen-specific tumor shrinkage without cytokinemia

Here, we introduce a double-stranded RNA mimic that is chemically synthesized to exclusively stimulate toll-like receptor 3 (TLR3). This function-defined TLR3 ligand, named ARNAX, acts as an adjuvant to induce antitumor CTL and NK without significant cytokinemia in mice, and thus superior to polyI:C...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Seya, Tsukasa, Takeda, Yohei, Matsumoto, Misako
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801468/
https://ncbi.nlm.nih.gov/pubmed/27057425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1043506
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