Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer

Monoclonal antibodies (mAbs) targeting coinhibitory molecules such as PD-1, PD-L1 and CTLA-4 are increasingly used as targets of therapeutic intervention against cancer. While these targets have led to a critical paradigm shift in treatments for cancer, these approaches are also plagued with limitat...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Mall, Christine, Sckisel, Gail D., Proia, David A., Mirsoian, Annie, Grossenbacher, Steven K., Pai, Chien-Chun Steven, Chen, Mingyi, Monjazeb, Arta M., Kelly, Karen, Blazar, Bruce R., Murphy, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801432/
https://ncbi.nlm.nih.gov/pubmed/27057446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1075114
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