Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Anti-tumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies

PURPOSE: Previous studies demonstrate that intratumoral CpG immunotherapy in combination with radiotherapy acts as an in-situ vaccine inducing anti-tumor immune responses capable of eradicating systemic disease. Unfortunately, most patients fail to respond. We hypothesized that immunotherapy can par...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Monjazeb, Arta M., Kent, Michael S., Grossenbacher, Steven K., Mall, Christine, Zamora, Anthony E., Mirsoian, Annie, Chen, Mingyi, Kol, Amir, Shiao, Stephen L., Reddy, Abhinav, Perks, Julian R., Culp, William, Sparger, Ellen E., Canter, Robert J., Sckisel, Gail D., Murphy, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010514/
https://ncbi.nlm.nih.gov/pubmed/26979392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-3026
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