TGF-β Tumor Suppression Through A Lethal EMT

TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers, exhibits frequent inactivation of the TGF-β mediator Smad4. We show that TGF-β induces an epithelial-mesenchymal transition...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: David, Charles J., Huang, Yun-Han, Chen, Mo, Su, Jie, Zou, Yilong, Bardeesy, Nabeel, Iacobuzio-Donahue, Christine A., Massagué, Joan
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801341/
https://ncbi.nlm.nih.gov/pubmed/26898331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.009
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