Cell-type–restricted anti-cytokine therapy: TNF inhibition from one pathogenic source

Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti-TNF therapy. TNF is produced by a variety of cell types, and it can play either a beneficial or a deleterious role. In particular, in autoimmunity pathogenic TNF may be deri...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Efimov, Grigory A., Kruglov, Andrei A., Khlopchatnikova, Zoya V., Rozov, Fedor N., Mokhonov, Vladislav V., Rose-John, Stefan, Scheller, Jürgen, Gordon, Siamon, Stacey, Martin, Drutskaya, Marina S., Tillib, Sergei V., Nedospasov, Sergei A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801281/
https://ncbi.nlm.nih.gov/pubmed/26936954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520175113
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