Mechanisms of backtrack recovery by RNA polymerases I and II

During DNA transcription, RNA polymerases often adopt inactive backtracked states. Recovery from backtracks can occur by 1D diffusion or cleavage of backtracked RNA, but how polymerases make this choice is unknown. Here, we use single-molecule optical tweezers experiments and stochastic theory to sh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Lisica, Ana, Engel, Christoph, Jahnel, Marcus, Roldán, Édgar, Galburt, Eric A., Cramer, Patrick, Grill, Stephan W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801279/
https://ncbi.nlm.nih.gov/pubmed/26929337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517011113
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