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A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency

Promoter-proximal pausing by RNA polymerase II (Pol II) is a key rate-limiting step in HIV-1 transcription and latency reversal. The viral Tat protein recruits human super elongation complexes (SECs) to paused Pol II to overcome this restriction. Despite the recent progress in understanding the func...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Li, Zichong, Lu, Huasong, Zhou, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800791/
https://ncbi.nlm.nih.gov/pubmed/26830226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00994-15
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