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A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency
Promoter-proximal pausing by RNA polymerase II (Pol II) is a key rate-limiting step in HIV-1 transcription and latency reversal. The viral Tat protein recruits human super elongation complexes (SECs) to paused Pol II to overcome this restriction. Despite the recent progress in understanding the func...
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Publicado no: | Mol Cell Biol |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Microbiology
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4800791/ https://ncbi.nlm.nih.gov/pubmed/26830226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00994-15 |
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