Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation

Scavenger receptor CD36 participates in lipid metabolism and inflammatory pathways important for cardiovascular disease and chronic kidney disease (CKD). Few pharmacological agents are available to slow the progression of CKD. However, apolipoprotein AI-mimetic peptide 5A antagonizes CD36 in vitro....

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Veröffentlicht in:Kidney Int
Hauptverfasser: Souza, Ana Carolina P., Bocharov, Alexander V., Baranova, Irina, Vishnyakova, Tatyana, Huang, Yuning G., Wilkins, Kenneth J., Hu, Xuzhen, Street, Jonathan M., Alvarez-Prats, Alejandro, Mullick, Adam E., Patterson, Amy P., Remaley, Alan, Eggerman, Thomas L., Yuen, Peter S.T., Star, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800337/
https://ncbi.nlm.nih.gov/pubmed/26994575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2015.12.043
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