Exenatide acutely increases heart rate in parallel with augmented sympathetic nervous system activation in healthy overweight males

AIM: Clinical use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) is consistently associated with heart rate (HR) acceleration in type 2 diabetes patients. We explored the mechanisms underlying this potential safety concern. METHODS: Ten healthy overweight males (aged 20–27 years) were examin...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Smits, Mark M., Muskiet, Marcel H. A., Tonneijck, Lennart, Hoekstra, Trynke, Kramer, Mark H. H., Diamant, Michaela, van Raalte, Daniël H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799913/
https://ncbi.nlm.nih.gov/pubmed/26609792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12843
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