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Circadian clocks govern calorie restriction–mediated life span extension through BMAL1- and IGF-1-dependent mechanisms
Calorie restriction (CR) increases longevity in many species by unknown mechanisms. The circadian clock was proposed as a potential mediator of CR. Deficiency of the core component of the circadian clock—transcriptional factor BMAL1 (brain and muscle ARNT [aryl hydrocarbon receptor nuclear transloca...
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| Publicado en: | FASEB J |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Federation of American Societies for Experimental Biology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4799504/ https://ncbi.nlm.nih.gov/pubmed/26700733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-282475 |
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