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Two-Stage Synapsis of DNA Ends during Non-Homologous End Joining

Repair of DNA double-strand breaks (DSBs) is essential for genomic stability. The most common DSB repair mechanism in human cells, non-homologous end joining (NHEJ), rejoins broken DNA ends by direct ligation. It remains unclear how components of the NHEJ machinery assemble a synaptic complex that b...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Graham, Thomas G.W., Walter, Johannes C., Loparo, Joseph J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799494/
https://ncbi.nlm.nih.gov/pubmed/26990988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.010
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