Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

BACKGROUND: Dimethylarginines (DMA) interfere with nitric oxide (NO) formation by inhibiting NO synthase (asymmetric dimethylarginine, ADMA) and L-arginine uptake into the cell (ADMA and symmetric dimethylarginine, SDMA). In prospective clinical studies ADMA has been characterized as a cardiovascula...

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Publicado no:Circ Cardiovasc Genet
Main Authors: Lüneburg, Nicole, Lieb, Wolfgang, Zeller, Tanja, Chen, Ming-Huei, Maas, Renke, Carter, Angela M., Xanthakis, Vanessa, Glazer, Nicole L, Schwedhelm, Edzard, Seshadri, Sudha, Ikram, M. Arfan, Longstreth, W.T., Fornage, Myriam, König, Inke R., Loley, Christina, Ojeda, Francisco M., Schillert, Arne, Wang, Thomas J., Sticht, Heinrich, Kittel, Anja, König, Jörg, Benjamin, Emelia J., Sullivan, Lisa M., Bernges, Isabel, Anderssohn, Maike, Ziegler, Andreas, Gieger, Christian, Illig, Thomas, Meisinger, Christa, Wichmann, H.-Erich, Wild, Philipp S., Schunkert, Heribert, Psaty, Bruce M., Wiggins, Kerri L., Heckbert, Susan R., Smith, Nicholas, Lackner, Karl, Lunetta, Kathryn L., Blankenberg, Stefan, Erdmann, Jeanette, Munzel, Thomas, Grant, Peter J., Vasan, Ramachandran S., Böger, Rainer H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797637/
https://ncbi.nlm.nih.gov/pubmed/25245031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000264
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