Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

BACKGROUND: Dimethylarginines (DMA) interfere with nitric oxide (NO) formation by inhibiting NO synthase (asymmetric dimethylarginine, ADMA) and L-arginine uptake into the cell (ADMA and symmetric dimethylarginine, SDMA). In prospective clinical studies ADMA has been characterized as a cardiovascula...

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Argitaratua izan da:Circ Cardiovasc Genet
Egile Nagusiak: Lüneburg, Nicole, Lieb, Wolfgang, Zeller, Tanja, Chen, Ming-Huei, Maas, Renke, Carter, Angela M., Xanthakis, Vanessa, Glazer, Nicole L, Schwedhelm, Edzard, Seshadri, Sudha, Ikram, M. Arfan, Longstreth, W.T., Fornage, Myriam, König, Inke R., Loley, Christina, Ojeda, Francisco M., Schillert, Arne, Wang, Thomas J., Sticht, Heinrich, Kittel, Anja, König, Jörg, Benjamin, Emelia J., Sullivan, Lisa M., Bernges, Isabel, Anderssohn, Maike, Ziegler, Andreas, Gieger, Christian, Illig, Thomas, Meisinger, Christa, Wichmann, H.-Erich, Wild, Philipp S., Schunkert, Heribert, Psaty, Bruce M., Wiggins, Kerri L., Heckbert, Susan R., Smith, Nicholas, Lackner, Karl, Lunetta, Kathryn L., Blankenberg, Stefan, Erdmann, Jeanette, Munzel, Thomas, Grant, Peter J., Vasan, Ramachandran S., Böger, Rainer H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797637/
https://ncbi.nlm.nih.gov/pubmed/25245031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000264
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