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Edd, the Murine Hyperplastic Disc Gene, Is Essential for Yolk Sac Vascularization and Chorioallantoic Fusion

EDD is the mammalian ortholog of the Drosophila melanogaster hyperplastic disc gene (hyd), which is critical for cell proliferation and differentiation in flies through regulation of hedgehog and decapentaplegic signaling. Amplification and overexpression of EDD occurs frequently in several cancers,...

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Published in:Mol Cell Biol
Main Authors: Saunders, Darren N., Hird, Samantha L., Withington, Sarah L., Dunwoodie, Sally L., Henderson, Michelle J., Biben, Christine, Sutherland, Robert L., Ormandy, Christopher J., Watts, Colin K. W.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2004
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479729/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15282321/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.16.7225-7234.2004
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