Structural characterization of a dimer of RNA duplexes composed of 8-bromoguanosine modified CGG trinucleotide repeats: a novel architecture of RNA quadruplexes

Fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS) are neurodegenerative disorders caused by the pathogenic expansion of CGG triplet repeats in the FMR1 gene. FXTAS is likely to be caused by a ‘toxic’ gain-of-function of the FMR1 mRNA. We provide evidence for the existence of...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Gudanis, Dorota, Popenda, Lukasz, Szpotkowski, Kamil, Kierzek, Ryszard, Gdaniec, Zofia
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Structural Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797283/
https://ncbi.nlm.nih.gov/pubmed/26743003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1534
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