Budding Yeast Silencing Complexes and Regulation of Sir2 Activity by Protein-Protein Interactions

Gene silencing in the budding yeast Saccharomyces cerevisiae requires the enzymatic activity of the Sir2 protein, a highly conserved NAD-dependent deacetylase. In order to study the activity of native Sir2, we purified and characterized two budding yeast Sir2 complexes: the Sir2/Sir4 complex, which...

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Опубликовано в::	Mol Cell Biol
Главные авторы:	Tanny, Jason C., Kirkpatrick, Donald S., Gerber, Scott A., Gygi, Steven P., Moazed, Danesh
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 2004
Предметы:	Transcriptional Regulation
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15282295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.16.6931-6946.2004
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