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Inhibition of Nuclear Import by the Proapoptotic Protein CC3
We report here that the normal cellular protein CC3/TIP30, when in excess, inhibits nuclear import in vitro and in vivo. CC3 binds directly to the karyopherins of the importin β family in a RanGTP-insensitive manner and associates with nucleoporins in vivo. CC3 inhibits the nuclear import of protein...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2004
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC479715/ https://ncbi.nlm.nih.gov/pubmed/15282309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7091-7101.2004 |
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