Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma

Few patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) achieve prolonged disease-free survival. Blinatumomab, a bispecific T-cell engaging antibody construct, transiently links CD3-positive T cells to CD19-positive B cells. This phase 2 study evaluated stepwise (9-28-112 μg/d wi...

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Vydáno v:Blood
Hlavní autoři: Viardot, Andreas, Goebeler, Marie-Elisabeth, Hess, Georg, Neumann, Svenja, Pfreundschuh, Michael, Adrian, Nicole, Zettl, Florian, Libicher, Martin, Sayehli, Cyrus, Stieglmaier, Julia, Zhang, Alicia, Nagorsen, Dirk, Bargou, Ralf C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797019/
https://ncbi.nlm.nih.gov/pubmed/26755709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-651380
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