Substrate engagement of integrins α(5)β(1) and α(v)β(3) is necessary, but not sufficient, for high directional persistence in migration on fibronectin

The interplay between specific integrin-mediated matrix adhesion and directional persistence in cell migration is not well understood. Here, we characterized fibroblast adhesion and migration on the extracellular matrix glycoproteins fibronectin and vitronectin, focusing on the role of α(5)β(1) and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Missirlis, Dimitris, Haraszti, Tamás, Scheele, Catharina v. C., Wiegand, Tina, Diaz, Carolina, Neubauer, Stefanie, Rechenmacher, Florian, Kessler, Horst, Spatz, Joachim P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796868/
https://ncbi.nlm.nih.gov/pubmed/26987342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23258
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge