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The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy
Mitochondrial quality control mechanisms have been implicated in protection against cardiac ischemia-reperfusion (IR) injury. Previously, cloxyquin (5-chloroquinolin-8-ol) was identified via phenotypic screening as a cardioprotective compound. Herein, cloxyquin was identified as a mitochondrial unco...
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| Published in: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Physiological Society
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4796459/ https://ncbi.nlm.nih.gov/pubmed/26519034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00926.2014 |
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