Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways

SCA1, a fatal neurodegenerative disorder, is caused by a CAG expansion encoding a polyglutamine stretch in the protein ATXN1. We used RNA sequencing to profile cerebellar gene expression in Pcp2-ATXN1[82Q] mice with ataxia and progressive pathology and Pcp2-ATXN1[30Q]D776 animals having ataxia in ab...

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Udgivet i:Neuron
Main Authors: Ingram, Melissa, Wozniak, Emily A. L., Duvick, Lisa, Yang, Rendong, Bergmann, Paul, Carson, Robert, O’Callaghan, Brennon, Zoghbi, Huda Y., Henzler, Christine, Orr, Harry T.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795980/
https://ncbi.nlm.nih.gov/pubmed/26948890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.02.011
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