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Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma
The secreted disulfide catalyst Quiescin sulfhydryl oxidase-1 (QSOX1) affects extracellular matrix organization and is overexpressed in various adenocarcinomas and associated stroma. Inhibition of extracellular human QSOX1 by a monoclonal antibody decreased tumor cell migration in a cell co-culture...
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| Publicado no: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4795942/ https://ncbi.nlm.nih.gov/pubmed/26819240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv067 |
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