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Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

The secreted disulfide catalyst Quiescin sulfhydryl oxidase-1 (QSOX1) affects extracellular matrix organization and is overexpressed in various adenocarcinomas and associated stroma. Inhibition of extracellular human QSOX1 by a monoclonal antibody decreased tumor cell migration in a cell co-culture...

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Foilsithe in:Protein Eng Des Sel
Main Authors: Grossman, Iris, Ilani, Tal, Fleishman, Sarel Jacob, Fass, Deborah
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795942/
https://ncbi.nlm.nih.gov/pubmed/26819240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv067
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