Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade

Hyperglycemia and hypertension impair endothelial function in part through oxidative stress-activated poly (ADP-ribose) polymerase 1 (PARP1). Biguanides and angiotensin II receptor blockers (ARBs) such as metformin and telmisartan have a vascular protective effect. We used cultured vascular endothel...

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Опубликовано в: :PLoS One
Главные авторы: Shang, Fenqing, Zhang, Jiao, Li, Zhao, Zhang, Jin, Yin, Yanjun, Wang, Yaqiong, Marin, Traci L., Gongol, Brendan, Xiao, Han, Zhang, You-yi, Chen, Zhen, Shyy, John Y-J, Lei, Ting
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795690/
https://ncbi.nlm.nih.gov/pubmed/26986624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151845
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