Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2. SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool

Lignende værker

• Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 1. SAR of modifications to the central aryl core
  af: Garcia-Barrantes, Pedro M., et al.
  Udgivet: (2015)
• Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
  af: Garcia-Barrantes, Pedro M., et al.
  Udgivet: (2016)
• Re-exploration of the mGlu(1) PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR
  af: Garcia-Barrantes, Pedro M., et al.
  Udgivet: (2016)
• Discovery of Molecular Switches within the ADX-47273 mGlu(5) PAM scaffold that modulate modes of pharmacology to afford potent mGlu(5) NAMs, PAMs and partial antagonists
  af: Lamb, Jeffrey P., et al.
  Udgivet: (2010)
• Discovery of VU6005649, a CNS Penetrant mGlu(7/8) Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines
  af: Abe, Masahito, et al.
  Udgivet: (2017)