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Codon Deletions in the Influenza A Virus PA Gene Generate Temperature-Sensitive Viruses
The influenza virus RNA-dependent RNA polymerase, which is composed of three subunits, PB1, PB2, and PA, catalyzes genome replication and transcription within the cell nucleus. The PA linker (residues 197 to 256) can be altered by nucleotide substitutions to engineer temperature-sensitive (ts), atte...
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| Publicado en: | J Virol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4794677/ https://ncbi.nlm.nih.gov/pubmed/26792748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03101-15 |
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