Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection

The cholesterol synthesis pathway is a ubiquitous cellular biosynthetic pathway that is attenuated therapeutically by statins. Importantly, type I interferon (IFN), a major antiviral mediator, also depresses the cholesterol synthesis pathway. Here we demonstrate that attenuation of cholesterol synth...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lange, Philip T., Darrah, Eric J., Vonderhaar, Emily P., Mboko, Wadzanai P., Rekow, Michaela M., Patel, Shailendra B., Sidjanin, Duska J., Tarakanova, Vera L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794672/
https://ncbi.nlm.nih.gov/pubmed/26739055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02277-15
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados