Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection

The cholesterol synthesis pathway is a ubiquitous cellular biosynthetic pathway that is attenuated therapeutically by statins. Importantly, type I interferon (IFN), a major antiviral mediator, also depresses the cholesterol synthesis pathway. Here we demonstrate that attenuation of cholesterol synth...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Lange, Philip T., Darrah, Eric J., Vonderhaar, Emily P., Mboko, Wadzanai P., Rekow, Michaela M., Patel, Shailendra B., Sidjanin, Duska J., Tarakanova, Vera L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Cellular Response to Infection
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794672/
https://ncbi.nlm.nih.gov/pubmed/26739055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02277-15
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