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Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion.

Treatment of chicken embryo fibroblasts (CEFs) with trypsin results in a dose- and time-dependent loss of phosphotyrosine from cellular proteins. A similar, but less marked, reduction in protein tyrosine phosphorylation occurs upon incubation of CEFs in phosphate-buffered saline (PBS). The decrease...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Author: Maher, P A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1993
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47945/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7504298/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.11177
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