Cancer-associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma

Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To address this question, we used Kras(LA1) mice, which develop lung adenocarcinomas from somatic activation of a Kras(G12D)...

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Publicado en:Mol Cancer Res
Autores principales: Pankova, Daniela, Chen, Yulong, Terajima, Masahiko, Schliekelman, Mark J., Baird, Brandi N., Fahrenholtz, Monica, Sun, Li, Gill, Bartley J., Vadakkan, Tegy J., Kim, Min P., Ahn, Young-Ho, Roybal, Jonathon D., Liu, Xin, Parra Cuentas, Edwin Roger, Rodriguez, Jaime, Wistuba, Ignacio I., Creighton, Chad J., Gibbons, Don L., Hicks, John M., Dickinson, Mary E., West, Jennifer L., Grande-Allen, K. Jane, Hanash, Samir M., Yamauchi, Mitsuo, Kurie, Jonathan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794404/
https://ncbi.nlm.nih.gov/pubmed/26631572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0307
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