Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links in cancer is still unclear. Here, we postulated that epithelial tumorigenes...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Chen, Yulong, Terajima, Masahiko, Yang, Yanan, Sun, Li, Ahn, Young-Ho, Pankova, Daniela, Puperi, Daniel S., Watanabe, Takeshi, Kim, Min P., Blackmon, Shanda H., Rodriguez, Jaime, Liu, Hui, Behrens, Carmen, Wistuba, Ignacio I., Minelli, Rosalba, Scott, Kenneth L., Sanchez-Adams, Johannah, Guilak, Farshid, Pati, Debananda, Thilaganathan, Nishan, Burns, Alan R., Creighton, Chad J., Martinez, Elisabeth D., Zal, Tomasz, Grande-Allen, K. Jane, Yamauchi, Mitsuo, Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362236/
https://ncbi.nlm.nih.gov/pubmed/25664850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74725
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