Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics

The relevance of sub-picosecond protein motions to the catalytic event remains a topic of debate. Heavy enzymes (isotopically substituted) provide an experimental tool for bond-vibrational links to enzyme catalysis. A recent transition path sampling study with heavy purine nucleoside phosphorylase (...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Zoi, Ioanna, Suarez, Javier, Antoniou, Dimitri, Cameron, Scott A., Schramm, Vern L., Schwartz, Steven D.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794390/
https://ncbi.nlm.nih.gov/pubmed/26927977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12551
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