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Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics
The relevance of sub-picosecond protein motions to the catalytic event remains a topic of debate. Heavy enzymes (isotopically substituted) provide an experimental tool for bond-vibrational links to enzyme catalysis. A recent transition path sampling study with heavy purine nucleoside phosphorylase (...
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| Vydáno v: | J Am Chem Soc |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4794390/ https://ncbi.nlm.nih.gov/pubmed/26927977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12551 |
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