A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of reexcision, and tailor adjuvant therapy. We used a protea...

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Vydáno v:Sci Transl Med
Hlavní autoři: Whitley, Melodi Javid, Cardona, Diana M., Lazarides, Alexander L., Spasojevic, Ivan, Ferrer, Jorge M., Cahill, Joan, Lee, Chang-Lung, Snuderl, Matija, Blazer, Dan G., Hwang, E. Shelley, Greenup, Rachel A., Mosca, Paul J., Mito, Jeffrey K., Cuneo, Kyle C., Larrier, Nicole A., O’Reilly, Erin K., Riedel, Richard F., Eward, William C., Strasfeld, David B., Fukumura, Dai, Jain, Rakesh K., Lee, W. David, Griffith, Linda G., Bawendi, Moungi G., Kirsch, David G., Brigman, Brian E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794335/
https://ncbi.nlm.nih.gov/pubmed/26738797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad0293
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